DoctorSolar

NanoViricides Reports That It is Financially Sound and is Progressing Towards Initial FDA Submission

More exciting news from the lottery ticket stock

Latest from our man Patrick Cox:

More Spectacular Data From NanoViricides

 

I've written for several weeks now as information is released about the HIV/AIDS animal tests from NanoViricides. Last week, I pointed out that the first-pass version of the HIVCide drug is as effective as the best HAART cocktail of AIDS drugs currently on the market. It will be cheaper, however, and viruses cannot develop a resistance to the therapy.

 

So let's think about what this therapy is worth. It is helpful, therefore, to look at the leading HAART cocktail, Gilead Sciences Inc.'s Atripla. This is the world's best-selling HIV therapy, but Gilead is currently in the process of replacing Atripla with a four-in-one combination pill. They are doing so for several reasons.

 

First, Atripla has too many side effects. Second, the HIV virus is learning to deal with existing HAART cocktails.

 

The FDA has determined that the new drug is "noninferior" to Atripla in terms of efficacy, but has fewer side effects. Last week, however, I showed you the data indicating that HIVCide will work as well, and there have been no side effects in animals. So what's it worth? According to Sanford C. Bernstein & Co. analyst Geoff Porges, in the linked article, Gilead's new drug sales could reach $4 billion annually.

 

As I said last week, there is every reason to believe that HIVCide's efficacy, which matches the cocktail approach in current animal tests, will dramatically improve. This is because the polymeric micelle portion of the NanoViricides technology was intentionally tuned down so that scientists could isolate the effectiveness of various biological ligands. When the micelles are tuned up and the ligands tailored for HIV, then we'll know exactly how much more effective the drug is.

 

There is another aspect to HIVCide that makes it attractive, however. I'm speaking of its dosing profile. In the tests, HIVCide was administered at much, much lower doses than the HAART drug.

 

Significantly, there were no side effects, which means that it is likely that HIVCide can be administered at even higher doses safely. At higher doses, the effectiveness against the virus increases. That alone should make HIVCide more effective than the best HAART cocktail. As significantly, however, the NanoViricides drug candidate remained active far longer than the HAART cocktail, which must be taken daily.

 

The press release states:

 

"The drug candidate, HIVCide, also showed a markedly lower total drug dose than standard highly active antiretroviral treatment (HAART) triple-drug cocktail therapy in a recent animal trial, the company said. The antiviral effect of HIVCide continued throughout the 48 days of the study, even though the HIVCide dosing was discontinued after 20 days. The company also said the HIVCide's clinical benefit continued for at least four weeks after the last drug dose."

 

This is extremely important. These mice are transgenic. When they are infected, human cells are infected. However, mice have much faster metabolisms than humans. Nevertheless, HIVCide remained in the animals' systems, effectively killing HIV viruses, for four weeks after the last dose was given. I expect that the drug will remain active in humans for three-six months, though the company is not saying this.

 

As the press releases says:

 

"Treatment with the drug reduced the HIV viral load and protected human T-cells (CD4+, CD8+) as effectively as treatment with the HAART cocktail at 24 days as well as at 48 days, the company said. There were no side effects or adverse effects observed for the HIVCide therapy group."

 

This means that dosing with HIVCide will be far more convenient than the daily HAART regimen. I predict that, eventually, HIVCide will be administered through a simple injection or skin patch once a month, or even less frequently.

 

Incidentally, these results have big implications for the company's influenza treatment, FluCide, and its herpes therapy. Because the drug is active far longer than it takes for the body to develop immunity to a flu virus, I predict that a single administration of FluCide will completely cure even the worst flu virus. Herpes could be controlled, perhaps, by quarterly treatments.

 

From the press release:

 

"The company said the sustained clinical benefit after stopping nanoviricide treatment is highly significant. Earlier, it saw a similar sustained reduction in viral for its anti-influenza FluCide drug candidate. The company uses nanoviricides made from a polymeric micelle structure designed to get a long circulating drug half-life in the body."

 

Remember, we are all about the long run. Think back to the Great Depression. People who invested in the big transformational technologies like electronics and artificial substances did not get rich immediately, but they got rich.

 

In times such as these, it's easy to get discouraged. Don't be. In five or 10 years, maybe less, people will look back and marvel at the people who had the foresight to buy transformational companies like NanoViricides and BioTime when the entire market seemed ready to jump off a building.

NanoViricides Expands On Prior HIVCide Effectiveness Release

the Company anticipates that HIVCide would be able to complement almost any of the various HAART therapy regimens and provide additional therapeutic benefits. The Company believes that such a combination therapy that includes HIVCide would possibly achieve a “functional cure” of HIV/AIDS.

Potential functional cure for HIV/AIDs folks. Admission price $1.18 per share. Oh and did I mention their platform also has candidates that might provide a cure for ALL of the following:

Influenza

Rabies

Ebola

Dengue

Herpes

We are on sale here and close to the 610 d MA.

Interesting, Doc S.

 

Here's the chart:

 

NNVC / NanoViricides Inc (OTC Bulletin Board Market) ... update : 5yr-chart

xx

 

If you see it near the 610d. MA, please let us know !

We are right on the 610d. MA right now. Thinking of taking a position?

I've been reading across on ADVFN IHUB. That DrFeelgood fellow points out that the recent test was more or less a gram for gram comparision. He suggests, the subject will be able to tolerate much larger doses of HIVCide as it supposedly produces no tox side effects.

 

Remember Oct' 09? I think that is what is in store if we are to shoot higher.

Do you think we are headed back to the Oct 09 lows?

I seem to remember they claimed HIVCide was thousands of percent more effective than HAART. Now it's only equivalent? What gives?

My thoughts exactly!

The guy seems to only have just realised that property should be sold - 4 years too late to take full advantage of the fact. As for the rest of the advice, well, keeping the house makes more sense as at least you will still have something left as opposed to nothing.

 

ETFs government and corporate bonds - banks and insurers - yeah!

 

He says that America will not default or devalue. Eh? The default will be de facto by devaluing - all the way down to zero.

 

Edit: And when did precious metals become 'rocks'? Why am I reading such drivel when I could be out on my bike!

Posted more for entertainment value than anything else. I'm not entirely sure why I continue to read his stuff. I guess mostly as I find him such a risible character. He has/had a pure hate on for the PMs and was flat out wrong. He also had a hate on for Canadian real estate and has been flat out wrong on that one too. At some point these items will fall of course and no doubt he will then crown himself a genius even though prices are still way above where he original said sell.

Following this guys advice so far has been a nasty road to the poor house....

Let's see how Garth's latest advice works out:

I’d exit precious metals. Anyone caught long in gold and silver in the months to come will get a real good lesson in the dangers of avarice. Have you made money in the past three years? Absolutely. So harvest that gain. Once it’s clear even to the sackcloth set that America will never default, never devalue, that minor European countries can keel over largely unnoticed and the global economy is actually expanding, PMs go back to being interesting rocks that impress dentists and werewolfs.

http://howestreet.com/2011/07/bet/

Silver Market Update

Yesterday's high volume breakout above its 50-day moving average marked completion of the intermediate basing pattern and the start of the next major uptrend in silver. Everything in now in place for a substantial uptrend to develop in coming months that should take silver comfortably to new highs.

The picture could not be more bullish.

I am amazed that the only post on the silver thread is bearish the same day that we are up over $2. This close above the $38 level seems significant. I think the $43 could easily be hit in August if not before. Time will tell.

Moi? I don't know what you mean

If you can get a place now with a good discount, then that might actually be near to where they nominally bottom out.

Part of me hopes this is true as I have just bought a place. But a larger part of me hopes we see deeper falls so we have fewer people being wage slaves to the banksters. I have kids to think about and hope they don't have to go through the madness of a housing bubble.

That's nothing new, it's been going on for years. We know several people that were doing this back in 2003 in the W.End Glasgow, and it was a buying frenzy back then.

Is it legal? Can anything be done to stop this kind of thing?

I guess there is no way for me to forewarn the potential buyers as I have no way of finding out who they are...

Here's a good example showing how desperate people are getting to sell... A friend has been unable to sell their lovely stone built victorian house for well over a year. They have dropped the price 20% but still no one will buy. They now have one note of interest but they have yet to put in an offer. To try and force their hand the sellers have now got another friend to get a solicitor to put in a note of interest too so they can go to a closing date. A complete shill bidder put there directly by the sellers in an effort to force someone in to bidding on a property.

Giving the potential buyer a false sense that other people are interested when in fact no one else is.

Completely outrageous behaviour and shows how desperate people are to keep the housing bubble fantasy prices alive.

Hmmm where exactly are all these cash rich buyers that are meant to be swooping in to buy these "bargains"?

Roll on the rolling eyes...

I viewed a number of nice old main door with garden tenement flats in some very nice areas of Edinburgh a few weeks back. The English old money was out in force viewing these places at the same time. I thought I wouldn't stand a chance of getting any of them so I didn't even bother bidding. Now I see these places are still on the market with prices dropped by 10%. All this talk that we are an island nation with a housing supply issue is certainly not helping prop up prices here. I thought all the cash rich buyers were meant to swoop in and pick up all these "bargains" now. Hmmm that turns out to be complete fantasy.

As I posted a few weeks back we are in the process of buying a place just now. Fortunately for us the seller had realised that the housing bubble party was over and cut us an OK deal. We can afford it but I am not daft enough to think I have bought an absolute bargain or that we have reached the bottom.

JD I await your rolling eyes emoticon with baited breath...

IKN

And this report from our man Patrick Cox:

NanoViricides Contracts With BCG for FDA Submission

 

Dear Breakthrough Technology Alert Readers,

 

I'm keeping this short today. Fortunately, I've got good news regarding NanoViricides Inc. (OTCBB: NNVC). With most other companies, the hiring of even a top firm to help with the FDA submission process might not be such a big thing. NanoViricides, however, is in a unique position.

 

The reason, of course, is that the company has the only technology that can directly shut down viruses in the bloodstream. It doesn't require any kind of immune system tweak and it involves no drugs, in the common sense of the word. At all. In a word, it is historic.

 

While other companies are working on various ways to vaccinate for viruses, NanoViricides' simple nanotech approach to influenza, dengue fever, Ebola and a host of other viruses is fundamentally mechanical. Signaling ligands are attached to polymer nanotech structures called micelles. These are the nanoviricides that lure viruses inside them, where they are trapped and harmlessly eliminated from the system.

 

I'm still amazed that the legacy media hasn't caught on to this astonishing technology, which is the most revolutionary implementation of nanomedicine to date. Nevertheless, the company's agreement with the renowned Biologics Consulting Group Inc. (BCG) to assist with FDA approval is a big deal.

 

Those of you who have been with me for a while remember when multiple analysts were claiming that NanoViricides was a scam and that I was part of the scam. In fact, I'm pretty sure that many of those making such claims were actually part of a scam themselves, trying their best to drive the stock price down, either to buy shares cheap or to short the company. We're seeing this same pattern of short attack on many of our companies right now. BioTime (AMEX: BTX) and Star Scientific (NASDAQ: CIGX) are most notable for the savagery and dishonesty of the attacks.

 

Regardless, the recent spectacular validation of NanoViricides' FluCide in animals, combined with the BCG agreement, puts the company on track to billion-dollar status. The use of BCG, by the way, is important because they specialize in biologics, which often face different regulatory issues than traditional drugs.

 

Remember also that NanoViricides has recently signed an agreement to rent and possibly acquire the structure for their own cGMP (current good manufacturing practice) facility. If you'd like an overview of this government-required facility, check this out.

NanoViricides Signs Consulting Agreement with BCG for FDA Submission

WEST HAVEN, Conn.--(BUSINESS WIRE)-- NanoViricides, Inc. (OTC BB: NNVC) (the "Company") announced today that it has entered into a consulting agreement with Biologics Consulting Group, Inc. (BCG) for the preparation and submission of Investigational New Drug (IND) applications to the FDA for its nanoviricides® drug candidates against various viral diseases

Good to see things are progressing Exciting times ahead CP

DS, where did u go? IND submission underway!

My apologies CP. I've been a little caught up with work and buying a house. Yes I know I know UK property is a daft thing to be buying but I've found somewhere we like and can now afford it and its a home for us etc etc... And I can afford to hold on to my holdings in NNVC

Anyways thanks for the heads up. I'll catch up on the developments now.

Cheers

<!--quoteo(post=190286:date=Oct 31 2010, 09:07 PM:name=azazel)--><div class='quotetop'>QUOTE (azazel @ Oct 31 2010, 09:07 PM) <a href="index.php?act=findpost&pid=190286"><{POST_SNAPBACK}></a></div><div class='quotemain'><!--quotec-->Can I get paid with £20 worth of silver please, even if its just a gram or even a scraping? Id rather not have that buttwipe stuff with Her majesty on it...<!--QuoteEnd--></div><!--QuoteEEnd-->

Sure thing! Same for me too if I am unfortunate enough to win.

Goldmoney or Bullionvault is easiest for me.

 

So the nationwide index is the one we shall use.

 

The October 2010 report can be found here:

 

<a href="http://www.nationwide.co.uk/hpi/historical/Oct_2010.pdf" target="_blank">http://www.nationwide.co.uk/hpi/historical/Oct_2010.pdf</a>

 

The average house price was: £164,381

 

So you need the average UK house price to go below: £131,505 to win

The June 2011 report can be found here:

http://www.nationwide.co.uk/hpi/historical/Jun_2011.pdf

The average house price was: £168,205

18 months to go on this bet. What's your thoughts on this one now?

Been a bit quiet here of late.

 

Bit of a lull in public searching for "silver bullion" too, it may pick up by mid-August though.

Ross Clark has been pretty good at calling the precious metals market.

He thinks we could see a rally out to end of August taking silver back to the $43 level.

http://talkdigitalnetwork.com/2011/07/week-money-23/

June 10 working out well so far. Now to remain patient and BTFD in early August.

Nice charts. If I am following the stair stepping pattern correctly then the forecasted August low should be approx £100 higher than the Feb low. The Feb low was £825 so the forthcoming August low would be projected as £925. Thats a tiny 2% drop from here.

Is this how you are interpreting it? If not why not?

Is it the rising wedge that is of concern?

Cheers

Well, it's happened, the £10,000 2-up 2-down Northern terrace is back.

 

Pugh's auction on 2nd June 2011, number 7 and number 9 Grange Street in Burnley were sold on behalf of the administrators for £8,000 and £9,500 respectively.

 

http://www.theauctionpeople.co/Lot/Manchester/20110602/119

http://www.theauctionpeople.co/Lot/Manchester/20110602/120

 

Some poor mortgage lender probably lent on them valued at £47,500 each back in February 2008 according to the land registry. The street looks like a prime mortgage fraud hotspot, too many double entries for the same house on the same date, but with different prices for me to believe otherwise.

 

http://www.houseprices.co.uk/e.php?q=grange+street%2C+burnley&n=100

 

Another 10 houses in Burnley at the same auction sold for between £10,000 and £20,000.

 

Apparently 12 Herbert Street which sold for £15,500 is tenanted and producing £4,420 per annum.

 

http://www.theauctionpeople.co/Lot/Manchester/20110602/141

 

Before your inner Rachman starts getting your chequebook out, tempted by that apparent 28.5% gross yield, remember that Burnley, while being in parts a rather nice faded industrial glory kind of place, in others is a racially divided hole.

<sarcasm>And there was me thinking that all these mega rich foreigners would pile in buying up any and all UK property thus ensuring that this kind of thing did not happen</sarcasm>

On the contrary, living by some railway lines is a great pleasure. Occasional trains, wending their way to mysterious or romantic destinations, all helping keep cars off the roads: it's a pleasure to watch and to listen to them.

 

There was a train line at the bottom of my garden in Coventry thirty years ago, and it was a joy. I'd pay more for the pleasure of it.

Well it all depends on how much traffic this line takes, at what times of day, are there freight train hurtling along at 3am? etc etc

I live directly opposite a major railway line and let me tell you it is a nightmare. Not so much due to the noise and rumble of trains but rather the amount of maintenance that goes on mostly scheduled between midnight and 5am. The noise levels are unbelievable. Thank god we are renting as I would not want to live here really long term. The woman downstairs actually went completely doolally recently with lack of sleep.

From "ladder" to "swamp".

 

That word "ladder" has always made me barf.

I wonder how sales are going at the quarter mile development in Edinburgh?

I see they are still asking for £400k for a two bed flat!

And only require a 5% deposit!

LUXURY LIVING JUST A 5% DEPOSIT AWAY

http://www.qmile.com/

 

The debt write off (reduction of mortgage debt for the "common" man) begins!

 

http://www.marketwatch.com/story/illinois-plan-to-cut-mortgage-debt-is-making-waves-2011-05-23?pagenumber=1

Err more like debt write off could maybe possibly start as long as a whole bunch of things come to pass :rolleyes:

needs the approval of the U.S. Treasury Department to move forward

Hi DS

 

Thanks for the reminder. I just emailed him.

 

I think its just been building energy for the last few months. Distribution. Maybe this will be the move to break out?

 

What news do you think it could be DS?

Their 10 Q is out:

http://xml.10kwizard.com/filing_raw.php?repo=tenk&ipage=7627855

Requirement for Additional Capital

 

As of March 31, 2011, we have a cash and cash equivalent balance of $7,763,391 which will be sufficient to fund our currently budgeted operations through December 31, 2012 at the Company’s current rate of expense.

 

We estimate that we will need approximately an additional $10M to $15M over the next 18 months for further development of our drug pipeline. These additional funds, if raised, will enable us to perform Toxicology Package Studies and additional efficacy studies necessary to prepare the full dataset required for filing our first Investigational New Drug Application (“IND”) with the US FDA on one of our drug candidates. The additional funds will also be needed to pay additional personnel, increased subcontract costs related to the expansion and further development of our drug pipeline, and for additional capital and operational expenditures required to file our first IND.

So looks like we have another 18 months before we get to file an IND with the FDA... hmmm it's tempting to bail now, focus on gold stocks and come back in a year...